In this 12-week randomized controlled trial, 100 healthy older adults (average age of 64 years; 65% female) with AAMI (based on the US National Institutes of Health criteria[1]) took either 500 mg/day of citicoline or a placebo.
The primary outcome was the raw change in short-term spatial memory. The secondary outcomes were the raw changes in working and episodic memory, short-term verbal memory, composite memory (a calculated measure of overall memory function), and selective and sustained attention.
Safety was assessed by asking participants open-ended questions regarding adverse events at weeks 0, 6 and 12.
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